Disease
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Diseases on Avlis require a +50% higher Save than the Bioware originals.
For example: The DC to thwart the least impressive diseases, such as Filth Fever, has climbed from 12 to 18. At the other extreme, you will need to beat a DC of 38 rather than 25, to survive the Soldier Shakes.
You can check the original DCs on the NWN Wiki.